CCR6 is required for ligand-induced CatSper activation in human sperm.

ABSTRACT: CatSper channel has been considered the principal sperm Ca²⁺ channel responsible for the cytosolic Ca²⁺ elevation required for various sperm functions necessary for fertilization [1-4]. However, the mechanism underlying the activation of CatSper channel by various physiological ligands remain incompletely understood. We have recently demonstrated the expression of C-C chemokine receptor 6 (CCR6) in sperm and Ca²⁺ influx upon binding of human β-defensin 1 (DEFB1) to CCR6, which is important for sperm motility [5]. In the present study, we have demonstrated that CCR6 receptor and CatSper channel are both required for the Ca²⁺ entry/current induced by physiological ligands DEFB1, chemokine (C-C motif) ligand 20 (CCL20) and progesterone in human sper

SUBMITTER: Diao R 

PROVIDER: S-EPMC5710936 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature