Integrative analysis to identify oncogenic gene expression changes associated with copy number variations of enhancer in ovarian cancer.

ABSTRACT: Enhancers are short regulatory regions (50-1500 bp) of DNA that control the tissue-specific activation of gene expression by long distance interaction with targeting gene regions. Recently, genome-wide identification of enhancers in diverse tissues and cell lines was achieved using high-throughput sequencing. Enhancers have been associated with malfunctions in cancer development resulting from point mutations in regulatory regions. However, the potential impact of copy number variations (CNVs) on enhancer regions is unknown. To learn more about the relationship between enhancers and cancer, we integrated the CNVs data on enhancers and explored their targeting gene expression pattern in high-grade ovarian cancer. Using human enhancer-gene interaction data with 13,691 interaction pairs betwe

SUBMITTER: Li X 

PROVIDER: S-EPMC5710946 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature