Comparison among conventional and advanced MRI, ¹⁸F-FDG PET/CT, phenotype and genotype in glioblastoma.

ABSTRACT: Glioblastoma (GB) is a highly heterogeneous tumor. In order to identify in vivo the most malignant tumor areas, the extent of tumor infiltration and the sites giving origin to GB stem cells (GSCs), we combined positron emission tomography/computed tomography (PET/CT) and conventional and advanced magnetic resonance imaging (MRI) with histology, immunohistochemistry and molecular genetics. Prior to dura opening and tumor resection, forty-eight biopsy specimens [23 of contrast-enhancing (CE) and 25 of non-contrast enhancing (NE) regions] from 12 GB patients were obtained by a frameless image-guided stereotactic biopsy technique. The highest values of 2-[18F]-fluoro-2-deoxy-D-glucose maximum standardized uptake value (¹⁸F-FDG SUV_max), relative cerebral blood volum

SUBMITTER: Valentini MC 

PROVIDER: S-EPMC5710953 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature