Metabomatching: Using genetic association to identify metabolites in proton NMR spectroscopy.

ABSTRACT: A metabolome-wide genome-wide association study (mGWAS) aims to discover the effects of genetic variants on metabolome phenotypes. Most mGWASes use as phenotypes concentrations of limited sets of metabolites that can be identified and quantified from spectral information. In contrast, in an untargeted mGWAS both identification and quantification are forgone and, instead, all measured metabolome features are tested for association with genetic variants. While the untargeted approach does not discard data that may have eluded identification, the interpretation of associated features remains a challenge. To address this issue, we developed metabomatching to identify the metabolites underlying significant associations observed in untargeted mGWASes on proton NMR metabolome data. Metabomatching

SUBMITTER: Rueedi R 

PROVIDER: S-EPMC5711027 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature