Metabolic Dysregulation, Systemic Inflammation, and Pediatric Obesity-related Asthma.

ABSTRACT: Obesity-related asthma is a distinct pediatric asthma phenotype. It is associated with higher disease burden, lower pulmonary function, and suboptimal response to current asthma medications. Recent studies have made inroads into elucidating its pathophysiology. Systemic immune responses in obese children with asthma are skewed to a nonatopic T-helper cell type 1 (Th1) pattern that correlates with pulmonary function deficits. The prevalence of metabolic dysregulation is also higher among obese children with asthma than among normal-weight children with asthma. Insulin resistance and dyslipidemia, particularly low levels of high-density lipoprotein (HDL), are associated with lower airway obstruction and low expiratory reserve volume. These associations are independent of truncal and general

SUBMITTER: Rastogi D 

PROVIDER: S-EPMC5711274 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature