Cardiac cycle-induced EPI time series fluctuations in the brain: Their temporal shifts, inflow effects and T₂^∗ fluctuations.

ABSTRACT: The cardiac-induced arterial pressure wave causes changes in cerebral blood flow velocities and volumes that affect the signals in echo-planar imaging (EPI). Using single-echo EPI time series data, acquired fast enough to unalias the cardiac frequency, we found that the cardiac cycle-induced signal fluctuations are delayed differentially in different brain regions. When referenced to the time series in larger arterial structures, the cortical voxels are only minimally shifted but significant shifts are observed in subcortical areas. Using double-echo EPI data we mapped the voxels' "signal at zero echo time", S₀, and apparent T₂^∗ over the cardiac cycle. S₀ pulsatility was maximised for voxels with a cardiac cycle-induced timing that was close to t

SUBMITTER: Viessmann O 

PROVIDER: S-EPMC5711428 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature