The evolving relationship between adiponectin and insulin sensitivity in hepatitis C patients during viral clearance.

ABSTRACT:

Background

The evolution of the relationship between adiponectin and insulin sensitivity in hepatitis C virus (HCV) patients during viral clearance is unclear and warrants investigation.

Methods

A prospective study including 747 consecutive chronic hepatitis C (CHC) patients, of whom 546 had completed a course of anti-HCV therapy and underwent pre-, peri- and post-therapy surveys for anthropomorphic, viral, metabolic and hepatic profiles and adiponectin levels, was conducted in a tertiary care center.

Results

Multivariate analyses indicated associations of sex, triglyceride levels and hepatic steatosis with adiponectin levels and of triglyceride levels and interferon λ3 (IFNL3) genotype with homeostasis model assessment-estimated insulin resistance (HOMA-IR) levels be

SUBMITTER: Chang ML 

PROVIDER: S-EPMC5711434 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature