Metabolic Phenotypes of Response to Vaccination in Humans.

ABSTRACT: Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available for prevention of shingles, its efficacy declines with age. To help to understand the mechanisms driving vaccinal responses, we constructed a multiscale, multifactorial response network (MMRN) of immunity in healthy young and older adults immunized with the live attenuated shingles vaccine Zostavax. Vaccination induces robust antigen-specific antibody, plasmablasts, and CD4⁺ T cells yet limited CD8⁺ T cell and antiviral responses. The MMRN reveals striking associations between orthogonal datasets, such as transcriptomic and metabolomics signatures, cell populations, and cytokine levels, and identifies immune and metabolic correlates of vac

SUBMITTER: Li S 

PROVIDER: S-EPMC5711477 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature