Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine.

ABSTRACT:

Objective

To determine outcomes among patients with migraine in the emergency department (ED) who receive IV hydromorphone vs IV prochlorperazine + diphenhydramine.

Methods

This study was conducted in 2 EDs in New York City. Patients who met international criteria for migraine were eligible for participation if they had not used an opioid within the previous month. Clinicians, participants, investigators, and research personnel were blinded to treatment. Patients were randomized in blocks of 4. Participants received hydromorphone 1 mg or prochlorperazine 10 mg + diphenhydramine 25 mg. Diphenhydramine was administered to prevent akathisia, a common side effect of IV prochlorperazine. The primary outcome was sustained headache relief, defined as achieving a headache level of m

SUBMITTER: Friedman BW 

PROVIDER: S-EPMC5711508 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature