PTSD Psychotherapy Outcome Predicted by Brain Activation During Emotional Reactivity and Regulation.

ABSTRACT:

Objective

Exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD), but many patients do not respond. Brain functions governing treatment outcome are not well characterized. The authors examined brain systems relevant to emotional reactivity and regulation, constructs that are thought to be central to PTSD and exposure therapy effects, to identify the functional traits of individuals most likely to benefit from treatment.

Method

Individuals with PTSD underwent functional MRI (fMRI) while completing three tasks assessing emotional reactivity and regulation. Participants were then randomly assigned to immediate prolonged exposure treatment (N=36) or a waiting list condition (N=30). A random subset of the prolonged exposure group (N=17) underwent sing

SUBMITTER: Fonzo GA 

PROVIDER: S-EPMC5711543 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature