Mimicking Embedded Vasculature Structure for 3D Cancer on a Chip Approaches through Micromilling.

ABSTRACT: The ability for cells to sense and respond to microenvironmental signals is influenced by their three dimensional (3D) surroundings, which includes the extracellular matrix (ECM). In the 3D environment, vascular structures supply cells with nutrients and oxygen thus affecting cell responses such as motility. Interpretation of cell motility studies though is often restricted by the applied approaches such as 2D conventional soft lithography methods that have rectangular channel cross-sectional morphology. To better simulate cell responses to vascular supply in 3D, we developed a cell on a chip system with microfluidic channels with curved cross-sections embedded within a 3D collagen matrix that emulates anatomical vasculature more closely than inorganic polymers, thus to mimic a more physio

SUBMITTER: Wan L 

PROVIDER: S-EPMC5711800 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature