Whitening and Impaired Glucose Utilization of Brown Adipose Tissue in a Rat Model of Type 2 Diabetes Mellitus.

ABSTRACT: Brown adipose tissue (BAT) is an attractive therapeutic target to combat diabetes and obesity due to its ability to increase glucose expenditure. In a genetic rat model (ZDF fa/fa) of type-2 diabetes and obesity, we aimed to investigate glucose utilization of BAT by ¹⁸F-FDG PET imaging. Male Zucker diabetic fatty (ZDF) and Male Zucker lean (ZL) control rats were studied at 13 weeks. Three weeks prior to imaging, ZDF rats were randomized into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group. Dynamic ¹⁸F-FDG PET using a dedicated small animal PET system was performed under hyperinsulinemic-euglycemic clamp. ¹⁸F-FDG PET identified intense inter-scapular BAT glucose uptake in all ZL control rats, while no focally increased ¹⁸F-

SUBMITTER: Lapa C 

PROVIDER: S-EPMC5711946 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature