Expression and evolutionary patterns of mycobacteriophage D29 and its temperate close relatives.

ABSTRACT:

Background

Mycobacteriophages are viruses that infect Mycobacterium hosts. A large collection of phages known to infect the same bacterial host strain - Mycobacterium smegmatis mc²155 - exhibit substantial diversity and characteristically mosaic architectures. The well-studied lytic mycobacteriophage D29 appears to be a deletion derivative of a putative temperate parent, although its parent has yet to be identified.

Results

Here we describe three newly-isolated temperate phages - Kerberos, Pomar16 and StarStuff - that are related to D29, and are predicted to be very close relatives of its putative temperate parent, revealing the repressor and additional genes that are lost in D29. Transcriptional profiles show the patterns of both lysogenic and lytic gene expressi

SUBMITTER: Dedrick RM 

PROVIDER: S-EPMC5712189 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature