In-utero cigarette smoke exposure and the risk of earlier menopause.

ABSTRACT:

Objective

Cigarette smoking is a risk factor for earlier menopause. Animal studies show that in-utero smoke exposure is toxic to developing ovaries. Our aim was to evaluate whether in-utero smoke exposed women reach menopause earlier compared with nonexposed women.

Methods

This is a cohort study within the Avon Longitudinal Study of Parents and Children. Participants included in this study were followed from 1991/1992 until 2010. Participant characteristics for the current analysis were obtained from obstetric records and from annual follow-up questionnaires. When not available, age at natural menopause was estimated by age at filling in the questionnaire minus 1 year. Cox proportional hazards modeling was used to estimate hazard ratios of menopause for in-utero exposed and

SUBMITTER: Honorato TC 

PROVIDER: S-EPMC5712220 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature