Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome.

ABSTRACT:

Background

Occupational vinyl chloride (VC) exposures have been associated with toxicant-associated steatohepatitis and liver cancer. Metabolomics has been used to clarify mode of action in drug-induced liver injury but has not been performed following VC exposures.

Methods

Plasma samples from 17 highly exposed VC workers without liver cancer and 27 unexposed healthy volunteers were obtained for metabolite extraction and GC/MS and LC/MS² analysis. Following ion identification/quantification, Ingenuity pathway analysis was performed.

Results

613 unique named metabolites were identified. Of these, 189 metabolites were increased in the VC exposure group while 94 metabolites were decreased. Random Forest analysis indicated that the metabolite signature could se

SUBMITTER: Guardiola JJ 

PROVIDER: S-EPMC5712227 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature