Thyroid-stimulating hormone, anti-thyroid antibodies, and pregnancy outcomes.

ABSTRACT:

Background

Overt thyroid dysfunction has been associated with adverse obstetric outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications.

Objective

The purpose of this study was to examine the association between prepregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery, gestational diabetes mellitus, and preeclampsia.

Study design

We conducted a secondary analysis of a prospective cohort of 18- to 40-year-old women with 1-2 previous pregnancy losses (n=1193) who participated in a multicenter randomized, placebo-controlled trial of low-dose aspirin. Prepregnancy levels of thyroid-stimulating hormone, free thyroxine, thyroglobulin antibody, and thyroid

SUBMITTER: Plowden TC 

PROVIDER: S-EPMC5712235 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature