Derivation of new equations to estimate glomerular filtration rate in pediatric oncology patients.

ABSTRACT:

Background and objective

Monitoring renal function is critical in treating pediatric patients, especially when dosing nephrotoxic agents. We evaluated the validity of the bedside Schwartz and Brandt equations in pediatric oncology patients and developed new equations for estimated glomerular filtration rate (eGFR) in these patients.

Methods

A retrospective analysis was conducted comparing eGFR using the bedside Schwartz and Brandt equations to measured GFR (mGFR) from technetium-99m diethylenetriamine pentaacetic acid (^99mTc-DTPA) between January 2007 and August 2013. An improved equation to estimate GFR was developed, simplified, and externally validated in a cohort of patients studied from September 2013 to June 2015. Carboplatin doses calculated from ^99m</

SUBMITTER: Millisor VE 

PROVIDER: S-EPMC5712286 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature