High Fat Diet Decreases Neuronal Activation in the Brain Induced by Resistin and Leptin.

ABSTRACT: Resistin and leptin are adipokines which act in the brain to regulate metabolic and cardiovascular functions which in some instances are similar, suggesting activation of some common brain pathways. High-fat feeding can reduce the number of activated neurons observed following the central administration of leptin in animals, but the effects on resistin are unknown. The present work compared the distribution of neurons in the brain that are activated by centrally administered resistin, or leptin alone, and, in combination, in rats fed a high fat (HFD) compared to a normal chow diet (ND). Immunohistochemistry for the protein, Fos, was used as a marker of activated neurons. The key findings are (i) following resistin or leptin, either alone or combined, in rats fed the HFD, there were no sign

SUBMITTER: Alsuhaymi N 

PROVIDER: S-EPMC5712409 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature