Identification of Biomarkers Correlated with the TNM Staging and Overall Survival of Patients with Bladder Cancer.

ABSTRACT: Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC). Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with tumor node metastasis (TNM) staging of BC patients. Functional enrichment analysis was conducted to functionally annotate the hub genes. Protein-protein interaction network analysis of hub genes was performed to identify the interactions among the hub genes. Survival analyses were conducted to characterize the role of hub genes on the survival of BC patients. Gene set enrichment analyses were conducted to find the potential mechanisms involved in the tumor proliferation promoted by hub genes. Results: Based on the resul

SUBMITTER: Li S 

PROVIDER: S-EPMC5712410 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature