Integrative gene network analysis identifies key signatures, intrinsic networks and host factors for influenza virus A infections.

ABSTRACT: Influenza A virus, with the limited coding capacity of 10-14 proteins, requires the host cellular machinery for many aspects of its life cycle. Knowledge of these host cell requirements not only reveals molecular pathways exploited by the virus or triggered by the immune system, but also provides further targets for antiviral drug development. To uncover novel pathways and key targets of influenza infection, we assembled a large amount of data from 12 cell-based gene-expression studies of influenza infection for an integrative network analysis. We systematically identified differentially expressed genes and gene co-expression networks induced by influenza infection. We revealed the dedicator of cytokinesis 5 (DOCK5) played potentially an important role for influenza virus replicatio

SUBMITTER: Forst CV 

PROVIDER: S-EPMC5712526 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature