Combination of Classifiers Identifies Fungal-Specific Activation of Lysosome Genes in Human Monocytes.

ABSTRACT: Blood stream infections can be caused by several pathogens such as viruses, fungi and bacteria and can cause severe clinical complications including sepsis. Delivery of appropriate and quick treatment is mandatory. However, it requires a rapid identification of the invading pathogen. The current gold standard for pathogen identification relies on blood cultures and these methods require a long time to gain the needed diagnosis. The use of in situ experiments attempts to identify pathogen specific immune responses but these often lead to heterogeneous biomarkers due to the high variability in methods and materials used. Using gene expression profiles for machine learning is a developing approach to discriminate between types of infection, but also shows a high degree of inconsistency

SUBMITTER: Leonor Fernandes Saraiva JP 

PROVIDER: S-EPMC5712586 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature