Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.

ABSTRACT: In mitochondria, the sirtuin SIRT5 is an NAD⁺-dependent protein deacylase that controls several metabolic pathways. Although a wide range of SIRT5 targets have been identified, the overall function of SIRT5 in organismal metabolic homeostasis remains unclear. Given that SIRT5 expression is highest in the heart and that sirtuins are commonly stress-response proteins, we used an established model of pressure overload-induced heart muscle hypertrophy caused by transverse aortic constriction (TAC) to determine SIRT5's role in cardiac stress responses. Remarkably, SIRT5KO mice had reduced survival upon TAC compared with wild-type mice but exhibited no mortality when undergoing a sham control operation. The increased mortality with TAC was associated with increased pathological hypert

SUBMITTER: Hershberger KA 

PROVIDER: S-EPMC5712617 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature