Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges.

ABSTRACT: Novel therapies are urgently needed to address the rising incidence and prevalence of acute kidney injury (AKI) and chronic kidney disease (CKD). Mesenchymal stem/stromal cells (MSCs) have shown promising results in experimental AKI and CKD, and have been used in the clinic for more than a decade with an excellent safety profile. The regenerative effects of MSCs do not rely on their differentiation and ability to replace damaged tissues, but are primarily mediated by the paracrine release of factors, including extracellular vesicles (EVs), composed of microvesicles and exosomes. MSC-derived EVs contain genetic and protein material that upon transferring to recipient cells can activate several repair mechanisms to ameliorate renal injury. Recent studies have shown that MSC-derived EV therap

SUBMITTER: Aghajani Nargesi A 

PROVIDER: S-EPMC5713024 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature