TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O₂ sensing.

ABSTRACT: Transient Receptor Potential (TRP) proteins form cation channels characterized by a wide variety of activation triggers. Here, we overview a group of TRP channels that respond to reactive redox species to transduce physiological signals, with a focus on TRPA1 and its role in oxygen physiology. Our systematic evaluation of oxidation sensitivity using cysteine-selective reactive disulphides with different redox potentials reveals that TRPA1 has the highest sensitivity to oxidants/electrophiles among the TRP channels, which enables it to sense O₂. Proline hydroxylation by O₂-dependent hydroxylases also regulates the O₂-sensing function by inhibiting TRPA1 in normoxia; TRPA1 is activated by hypoxia through relief from the inhibition and by hyperoxia through cys

SUBMITTER: Mori Y 

PROVIDER: S-EPMC5713176 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature