Reg Gene Expression in Periosteum after Fracture and Its In Vitro Induction Triggered by IL-6.

ABSTRACT: The periosteum is a thin membrane that surrounds the outer surface of bones and participates in fracture healing. However, the molecular signals that trigger/initiate the periosteal reaction are not well established. We fractured the rat femoral bone at the diaphysis and fixed it with an intramedullary inserted wire, and the expression of regenerating gene (Reg) I, which encodes a tissue regeneration/growth factor, was analyzed. Neither bone/marrow nor muscle showed RegI gene expression before or after the fracture. By contrast, the periosteum showed an elevated expression after the fracture, thereby confirming the localization of Reg I expression exclusively in the periosteum around the fractured areas. Expression of the Reg family increased after the fracture, followed by a decrease to b

SUBMITTER: Tohma Y 

PROVIDER: S-EPMC5713227 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature