Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms.

ABSTRACT: Cancer therapies targeting epidermal growth factor receptor (EGFR), such as small-molecule kinase inhibitors and monoclonal antibodies, have been developed as standard therapies for several cancers, such as non-small cell lung cancer, colorectal cancer, pancreatic cancer, breast cancer, and squamous cell carcinoma of the head and neck. Although these therapies can significantly prolong progression-free survival, curative effects are not often achieved because of intrinsic and/or acquired resistance. The resistance mechanisms to EGFR-targeted therapies can be categorized as resistant gene mutations, activation of alternative pathways, phenotypic transformation, and resistance to apoptotic cell death. Analysis of the processes that modulate EGFR signal transduction by EGFR-targeted inhibitor

SUBMITTER: Yamaoka T 

PROVIDER: S-EPMC5713388 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature