Computational Methods for Modeling Aptamers and Designing Riboswitches.

ABSTRACT: Riboswitches, which are located within certain noncoding RNA region perform functions as genetic "switches", regulating when and where genes are expressed in response to certain ligands. Understanding the numerous functions of riboswitches requires computation models to predict structures and structural changes of the aptamer domains. Although aptamers often form a complex structure, computational approaches, such as RNAComposer and Rosetta, have already been applied to model the tertiary (three-dimensional (3D)) structure for several aptamers. As structural changes in aptamers must be achieved within the certain time window for effective regulation, kinetics is another key point for understanding aptamer function in riboswitch-mediated gene regulation. The coarse-grained self-organized po

SUBMITTER: Gong S 

PROVIDER: S-EPMC5713409 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature