Diagnostic significance of circulating long noncoding RNA PCAT6 in patients with non-small cell lung cancer.

ABSTRACT:

Aim

We have previously shown that the long noncoding RNA prostate cancer-associated transcript 6 (PCAT6) promoted the proliferation and invasion of lung adenocarcinoma (LUAD) cells. In this study, the diagnostic significance of tissue and serum PCAT6 was evaluated in non-small cell lung cancer (NSCLC).

Materials and methods

Tissue expression of PCAT6 was systematically evaluated in five Gene Expression Omnibus datasets (GSE19804, GSE18842, GSE30219, GSE19188, and GSE27262). Circulating and tissue expressions of PCAT6 were detected by quantitative reverse-transcriptase polymerase chain reaction in NSCLC patients from Union Hospital.

Results

PCAT6 was significantly increased in lung cancer tissues and could be used to distinguish LUAD from adjacent normal tissues with a

SUBMITTER: Wan L 

PROVIDER: S-EPMC5713690 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature