Determinants of exacerbation risk in patients with COPD in the TIOSPIR study.

ABSTRACT:

Background

Exacerbation history is used to grade the risk of COPD exacerbation, but its reliability and relationship to other risk factors and prior therapy is unclear. To examine these interrelationships, we conducted a post hoc analysis of patients in the TIOSPIR trial with ≥2 years' follow-up or who died on treatment.

Patients and methods

Patients were grouped by their annual exacerbation rate on treatment into nonexacerbators, infrequent, and frequent exacerbators (annual exacerbation rates 0, ≤1, and >1, respectively), and baseline characteristics discriminating among the groups were determined. We used univariate and multivariate analyses to explore the effect of baseline characteristics on risk of exacerbation, hospitalization (severe exacerbation), and death (all cau

SUBMITTER: Calverley PM 

PROVIDER: S-EPMC5713692 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature