The effect of medication nonadherence on progression-free survival among patients with renal cell carcinoma.

ABSTRACT:

Objective

To examine how observed medication nonadherence to 2 second-line, oral anticancer medications (axitinib and everolimus) affects progression-free survival (PFS) among patients with renal cell carcinoma.

Methods

We used an adherence-exposure-outcome model to simulate the impact of adherence on PFS. Using a pharmacokinetic/pharmacodynamic (PK/PD) population model, we simulated drug exposure measured by area under the plasma concentration-time curve (AUC) and minimum blood or trough concentration (C_min) under 2 scenarios: 1) optimal adherence and 2) real-world adherence. Real-world adherence was measured using the medication possession ratios as calculated from health insurance claims data. A population PK/PD model was simulated on individuals drawn from the

SUBMITTER: Shafrin J 

PROVIDER: S-EPMC5713701 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature