Pre-microRNA Gene Polymorphisms and Risk of Cervical Squamous Cell Carcinoma.

ABSTRACT:

Introduction

MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases, including cancer. It has been suggested that, the presence of single nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA processing, expression and binding to target mRNA and represents another type of genetic variability, that can contribute to the susceptibility of human cancers.

Aim

The present study investigated the genetic variants in pre-miRNAs (hsa-miRNA-196a2 rs11614913 C/T, hsa-miRNA-499 rs3746444 T/C and hsa-miRNA-146a rs2910164 G/C) for their role in cervical cancer susceptibility.

Materials and methods

The study comprised 164 controls and 184 patients of cervical cancer. The genot

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC5713754 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature