Association of Sickle Cell Trait With Hemoglobin A1c in African Americans.

ABSTRACT:

Importance

Hemoglobin A1c (HbA1c) reflects past glucose concentrations, but this relationship may differ between those with sickle cell trait (SCT) and those without it.

Objective

To evaluate the association between SCT and HbA1c for given levels of fasting or 2-hour glucose levels among African Americans.

Design, setting, and participants

Retrospective cohort study using data collected from 7938 participants in 2 community-based cohorts, the Coronary Artery Risk Development in Young Adults (CARDIA) study and the Jackson Heart Study (JHS). From the CARDIA study, 2637 patients contributed a maximum of 2 visits (2005-2011); from the JHS, 5301 participants contributed a maximum of 3 visits (2000-2013). All visits were scheduled at approximately 5-year intervals. Particip

SUBMITTER: Lacy ME 

PROVIDER: S-EPMC5713881 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature