QRS/T-wave and calcium alternans in a type I diabetic mouse model for spontaneous postmyocardial infarction ventricular tachycardia: A mechanism for the antiarrhythmic effect of statins.

ABSTRACT:

Background

The incidence of sudden arrhythmic death is markedly increased in diabetics.

Objective

The purpose of this study was to develop a mouse model for postmyocardial infarction (post-MI) ventricular tachycardia (VT) in the diabetic heart and determine the mechanism of an antiarrhythmic effect of statins.

Methods

ECG transmitters were implanted in wild-type (WT), placebo, and pravastatin-treated type I diabetic Akita mice. MIs were induced by coronary ligation, and Ca²⁺ transients were studied by optical mapping, and Ca²⁺ transients and sparks in left ventricular myocytes (VM) by the Ionoptix system and confocal microscopy.

Results

Burst pacing of Akita mouse hearts resulted in rate-related QRS/T-wave alternans, which was attenuated i

SUBMITTER: Jin H 

PROVIDER: S-EPMC5713915 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature