A Trishistidine Pseudopeptide with Ability to Remove Both Cu^Ι and Cu^ΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation.

ABSTRACT: The pseudopeptide L, derived from a nitrilotriacetic acid scaffold and functionalized with three histidine moieties, is reminiscent of the amino acid side chains encountered in the Alzheimer's peptide (Aβ). Its synthesis and coordination properties for Cu^Ι and Cu^ΙΙ are described. L efficiently complex Cu^ΙΙ in a square-planar geometry involving three imidazole nitrogen atoms and an amidate-Cu bond. By contrast, Cu^Ι is coordinated in a tetrahedral environment. The redox behavior is irreversible and follows an ECEC mechanism in accordance with the very different environments of the two redox states of the Cu center. This is in line with the observed resistance of the Cu^Ι complex to oxidation by oxygen and the Cu^ΙΙ complex reduc

SUBMITTER: Conte-Daban A 

PROVIDER: S-EPMC5714062 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature