Skiving stacked sheets of paper into test paper for rapid and multiplexed assay.

ABSTRACT: This paper shows that stacked sheets of paper preincubated with different biological reagents and skiving them into uniform test paper sheets allow mass manufacturing of multiplexed immunoassay devices and simultaneous detection of multiplex targets that can be read out by a barcode scanner. The thickness of one sheet of paper can form the width of a module for the barcode; when stacked, these sheets of paper can form a series of barcodes representing the targets, depending on the color contrast provided by a colored precipitate of an immunoassay. The uniform thickness of sheets of paper allows high-quality signal readout. The manufacturing method allows highly efficient fabrication of the materials and substrates for a straightforward assay of targets that range from drugs of abuse to bio

SUBMITTER: Yang M 

PROVIDER: S-EPMC5714065 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature