Association between insulin resistance and preeclampsia in obese non-diabetic women receiving metformin.

ABSTRACT:

Objectives

To examine whether the reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is mediated by changes in insulin resistance.

Methods

This was a secondary analysis of obese pregnant women in a randomised trial (MOP trial). Fasting plasma glucose and insulin were measured in 384 of the 400 women who participated in the MOP trial. Homeostasis model assessment of insulin resistance (HOMA-IR) was compared in the metformin and placebo groups and in those that developed preeclampsia versus those that did not develop preeclampsia.

Results

At 28 weeks, median HOMA-IR was significantly lower in the metformin group. Logistic regression analysis demonstrated that there was a significant contribution in the prediction of preeclampsi

SUBMITTER: Balani J 

PROVIDER: S-EPMC5714110 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature