Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation.

ABSTRACT:

Background

Ambient particulate matter (PM) air pollution exposure has been associated with increases in QT interval duration (QT). However, innate susceptibility to PM-associated QT prolongation has not been characterized.

Objective

To characterize genetic susceptibility to PM-associated QT prolongation in a multi-racial/ethnic, genome-wide association study (GWAS).

Methods

Using repeated electrocardiograms (1986–2004), longitudinal data on PM<10 μm in diameter (PM₁₀), and generalized estimating equations methods adapted for low-prevalence exposure, we estimated approximately 2.5×10⁶ SNP×PM₁₀ interactions among nine Women’s Health Initiative clinical trials and Atherosclerosis Risk in Communities Study subpopulations (n=22,158), then c

SUBMITTER: Gondalia R 

PROVIDER: S-EPMC5714283 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature