Metabolic Dysregulation after Neutron Exposures Expected from an Improvised Nuclear Device.

ABSTRACT: The increased threat of terrorism across the globe has raised fears that certain groups will acquire and use radioactive materials to inflict maximum damage. In the event that an improvised nuclear device (IND) is detonated, a potentially large population of victims will require assessment for radiation exposure. While photons will contribute to a major portion of the dose, neutrons may be responsible for the severity of the biologic effects and cellular responses. We investigated differences in response between these two radiation types by using metabolomics and lipidomics to identify biomarkers in urine and blood of wild-type C57BL/6 male mice. Identification of metabolites was based on a 1 Gy dose of radiation. Compared to X rays, a neutron spectrum similar to that encountered in Hirosh

SUBMITTER: Laiakis EC 

PROVIDER: S-EPMC5714588 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature