Activation of 5-HT_2A receptor disrupts rat maternal behavior.

ABSTRACT: Serotonin 5-HT_2A receptor is widely distributed in the central nervous system and plays an important role in sensorimotor function, emotion regulation, motivation, executive control, learning and memory. We investigated its role in rat maternal behavior, a naturalistic behavior encompassing many psychological functions that the 5-HT_2A receptor is involved in. We first showed that activation of 5-HT_2A receptor by TCB-2 (a highly selective 5-HT_2A agonist, 1, 2.5 or 5.0 mg/kg) disrupted maternal behavior dose-dependently, and this effect was reduced by pretreatment with a 5-HT_2A receptor antagonist MDL 100907, but exacerbated by pretreatment with a 5-HT_2C receptor antagonist SB242084 and a 5-HT_2C receptor agonist MK2

SUBMITTER: Gao J 

PROVIDER: S-EPMC5714678 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature