A Genome-Wide Association Study Identifies UTRN Gene Polymorphism for Restless Legs Syndrome in a Korean Population.

ABSTRACT:

Objective

Restless legs syndrome (RLS) is a highly heritable and common neurological sensorimotor disease disturbing sleep. The objective of study was to investigate significant gene for RLS by performing GWA and replication study in a Korean population.

Methods

We performed a GWA study for RLS symptom group (n=325) and non-RLS group (n=2,603) from the Korea Genome Epidemiology Study. We subsequently performed a replication study in RLS and normal controls (227 RLS and 229 controls) to confirm the present GWA study findings as well as previous GWA study results.

Results

In the initial GWA study of RLS, we observed an association of rs11645604 (OR=1.531, p=1.18×10^-6) in MPHOSPH6 on chromosome 16q23.3, rs1918752 (OR=0.6582, p=1.93×10^-6) and

SUBMITTER: Cho CH 

PROVIDER: S-EPMC5714726 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature