Whole Brain Voxel-Wise Analysis of Cerebral Retention of Beta-Amyloid in Cognitively Normal Older Adults Using ¹⁸F-Florbetaben.

ABSTRACT:

Objective

Recently developed 18F-labelled amyloid beta (Aβ) positron emission tomography (PET) tracers have demonstrated potentials to enable more prevalent application of amyloid imaging in the clinical setting. The aim of this study is to demonstrate cerebral retention of Aβ in cognitively normal older adults, by implementing voxel-based analysis on images acquired from ¹⁸F-Florbetaben amyloid PET.

Methods

Fifty cognitive normal elderly subjects were recruited and included in the study. Demographic data and cognitive measurements were collected. Magnetic resonance imaging (MRI) and ¹⁸F-Florbetaben PET data were obtained followed by whole brain voxel-based analysis.

Results

Compared to the florbetaben (FBB) (-) counterpart, FBB (+) showed signif

SUBMITTER: Um YH 

PROVIDER: S-EPMC5714734 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature