Exosomal TGF-β1 is correlated with lymphatic metastasis of gastric cancers.

ABSTRACT: Exosomes are nano-vesicles transporting bioactive material between cells. This study explored the prognostic association of exosomal TGF-β1 with lymph node (LN) metastasis of gastric cancer (GC). TGF-β1 expressions in the exosomes isolated from the gastroepiploic veins of 61 GC patients analyzed by ELISA. The regulatory T (Treg) cells in celiac LNs of gastric cancer analyzed by immunohistochemistry. Exosomal TGF-β1 expression and the ratio of Treg cells in draining LNs were both significantly associated with pathological stages and LN metastasis of gastric cancer. Besides, the exosomal TGF-β1 expression and Treg proportion in LN were also significantly correlated in gastric cancer patients. Recombinant TGF-β1 and exosomes isolated from GC patients were used to induce FOXP3⁺ Treg

SUBMITTER: Yen EY 

PROVIDER: S-EPMC5714749 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature