Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.

ABSTRACT: Esophageal squamous cell carcinoma (ESCC) is widely regarded as one of the most lethal types of cancer around the world. The fact that early detection of ESCC could dramatically improve the treatment outcome of the patients has sparked considerable interest in searching for reliable and accurate diagnostic biomarkers. Recently, circular RNAs (circRNA) have emerged as a new type of non-coding RNAs with significant RNase resistance, wide abundance and remarkable internal diversity. There is also increasing evidence suggesting that circRNAs could be implicated in the pathogenesis of cancer and other diseases. In this study, we performed a comparative analysis of the global circRNA expression profiles in normal and malignant esophageal epithelial cell lines by a combination of RNA sequencing a

SUBMITTER: Sun J 

PROVIDER: S-EPMC5714800 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature