The role of gene polymorphisms and AMH level in prediction of poor ovarian response in Egyptian women undergoing IVF procedure.

ABSTRACT:

Objective

The aim of this study is to assess the role of AMH in prediction of poor ovarian response as well as the relation between ESR ₂ (+ 1730G>A) (rs4986938) and FSHR p.Thr³⁰⁷Ala (c.919A>G, rs6165) SNPs and the poor ovarian response in Egyptian women undergoing IVF procedure. Discovering the genetic variants associated with ovarian response is an important step towards individualized pharmacogenetic protocols of ovarian stimulation.

Methods

We performed a prospective study on 216 young women with unexplained infertility. Ovarian stimulation was performed according to the GnRH antagonist protocol with a fixed daily morning dose of human menopausal gonadotrophin (HMG). The estrogen receptor (ESR2) (+ 1730G>A) (rs4986938) and FSH receptor p.Thr307Ala (

SUBMITTER: Motawi TMK 

PROVIDER: S-EPMC5714814 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature