Endometriosis-associated infertility: GDF-9, AMH, and AMHR2 genes polymorphisms.

ABSTRACT:

Purpose

The purpose of this paper is to determine whether there is a correlation between polymorphisms in the growth differentiation factor-9 (GDF-9) gene and anti-Müllerian hormone (AMH) gene and its receptor, AMHR2, and endometriosis-associated infertility.

Methods

This is a case-control study to evaluate whether there is a correlation between polymorphisms in the GDF-9 gene (SNPs determined by direct sequencing), AMH gene, AMHR2 (both SNPs determined by genotyping using TaqMan Allelic Discrimination), and endometriosis-associated infertility. The study included 74 infertile women with endometriosis and 70 fertile women (tubal ligation) as a control group.

Results

Patient age and the mean FSH levels were similar between the infertile with endometriosis and fertile w

SUBMITTER: De Conto E 

PROVIDER: S-EPMC5714819 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature