Differences in Exercise Capacity and Responses to Training in 24 Inbred Mouse Strains.

ABSTRACT: Changes in cardiorespiratory fitness in response to a standardized exercise training protocol differ substantially between individuals. Results from cross-sectional, twin, and family studies indicate genetics contribute to individual differences in both baseline exercise capacity and the response to training. Exercise capacity and responses to training also vary between inbred strains of mice. However, such studies have utilized a limited number of inbred strains. Therefore, the aim of this study was to characterize exercise-training responses in a larger number of genetically diverse strains of inbred mice and estimate the contribution of genetic background to exercise training responses. Eight-week old male mice from 24 inbred strains (n = 4-10/strain) performed a graded exercise

SUBMITTER: Avila JJ 

PROVIDER: S-EPMC5714923 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature