The Different Faces of Rolling-Circle Replication and Its Multifunctional Initiator Proteins.

ABSTRACT: Horizontal gene transfer (HGT) contributes greatly to the plasticity and evolution of prokaryotic and eukaryotic genomes. The main carriers of foreign DNA in HGT are mobile genetic elements (MGEs) that have extremely diverse genetic structures and properties. Various strategies are used for the maintenance and spread of MGEs, including (i) vegetative replication, (ii) transposition (and other types of recombination), and (iii) conjugal transfer. In many MGEs, all of these processes are dependent on rolling-circle replication (RCR). RCR is one of the most well characterized models of DNA replication. Although many studies have focused on describing its mechanism, the role of replication initiator proteins has only recently been subject to in-depth analysis, which indicates their involvement

SUBMITTER: Wawrzyniak P 

PROVIDER: S-EPMC5714925 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature