Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults.

ABSTRACT: Childhood obesity coincides with increased numbers of circulating classical CD14⁺⁺CD16^- and intermediate CD14⁺⁺CD16⁺ monocytes. Monocytes are key players in the development and exacerbation of atherosclerosis, which prompts the question as to whether the monocytosis in childhood obesity contributes to atherogenesis over the years. Here, we dissected the monocyte gene expression profile in childhood obesity using an Illumina microarray platform on sorted monocytes of 35 obese children and 16 lean controls. Obese children displayed a distinctive monocyte gene expression profile compared to lean controls. Upon validation with quantitative PCR, we studied the association of the top 5 differentially regulated monocyte genes in childhood obesity with o

SUBMITTER: Keustermans GC 

PROVIDER: S-EPMC5714995 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature