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Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model.

ABSTRACT: As cryo-electron microscopy (cryo-EM) enters mainstream structural biology, the demand for fitting methods is high. Here, we review existing flexible fitting methods for cryo-EM. We discuss their importance, potential concerns and assessment strategies. We aim to give readers concrete descriptions of cryo-EM flexible fitting methods with corresponding examples.

SUBMITTER: Kim DN 

PROVIDER: S-EPMC5715128 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model.

Kim Doo Nam DN   Sanbonmatsu Karissa Y KY  

Bioscience reports 20171205 6

As cryo-electron microscopy (cryo-EM) enters mainstream structural biology, the demand for fitting methods is high. Here, we review existing flexible fitting methods for cryo-EM. We discuss their importance, potential concerns and assessment strategies. We aim to give readers concrete descriptions of cryo-EM flexible fitting methods with corresponding examples. ...[more]

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