Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation.

ABSTRACT: α-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone derivatives in typically good yields.

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC5715285 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature